A beach with waves, a boat, and palm trees.

Santa Clara Vacation Packages

Book a Hotel + Flight or Car together to unlock savings

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    Save up to CA $4,200 when you book a flight and hotel together*

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    With over 300,000 hotels worldwide, it's easy to create a perfect package

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Your Santa Clara Vacation

Lock in a Santa Clara vacation package that has everything you need without any unnecessary extras. Great for distilleries and craft breweries, bars and pubs and cafes, think about staying in the neighborhood of El Cangrejo. A trip to Santa Clara is an excellent opportunity to take in the sights. Make sure you visit big-name attractions such as Multiplaza Pacific Mall, Avenida Balboa and Via Espana. A few clicks is all it takes to create a customized Santa Clara vacation on Expedia.

The Latest Santa Clara Vacation Packages

Price found within the past 48 hours. Click for updated prices.
  • A pool area with lounge chairs, umbrellas, and a bridge over the water.
    Jan 8 - Jan 12

    Riande Aeropuerto Hotel & Casino + Flight

    Tocumen Airport
    4 nights
    4.0 star property
    8.6/10 - Excellent (1,813 reviews)
    Roundtrip • Toronto (YTO) - Panama City (PTY)
    YYZ - PTY • 1 stop PTY - YYZ • 2 stops
    CA $1,757
    CA $1,259
    per traveller
    found 1 day ago
    Riande Aeropuerto Hotel & Casino
  • A multi-story building with balconies, arched windows, and decorative railings.
    Dec 7 - Dec 11

    Central Hotel Panama Casco Viejo + Flight

    Casco Viejo
    4 nights
    4.0 star property
    9.2/10 - Wonderful (1,003 reviews)
    "In the heart of Casco Viejo, the first hotel built but you could not tell as it has been remodeled. A lot of history. The place is beautiful and well maintained. We went on a sailing trip for 2 days and the held our bags at no extra cost. The staff is great and the restaurant in the back is absolutely delicious! Lots of great restaurants around as well. There is a Speakeasy nearby called Villa Ana 1928, second floor above the restaurant, don’t miss it!"
    Reviewed November 5, 2026
    Roundtrip • Toronto (YTO) - Panama City (PTY)
    YYZ - PTY • Nonstop PTY - YYZ • Nonstop
    Save 100% on your flight
    CA $2,516
    CA $1,360
    per traveller
    found 1 day ago
    Central Hotel Panama Casco Viejo
  • A high-rise building with a modern architectural design, featuring a grid of windows and balconies.
    Dec 28 - Jan 3

    Megapolis Hotel Panamá + Flight

    San Francisco
    6 nights
    4.5 star property
    8.6/10 - Excellent (1,841 reviews)
    "Shops nearby"
    Reviewed November 6, 2026
    Roundtrip • Toronto (YTO) - Panama City (PTY)
    YYZ - PTY • 1 stop PTY - YYZ • 1 stop
    CA $4,492
    CA $2,758
    per traveller
    found 1 day ago
    Megapolis Hotel Panamá
  • A modern interior with a spiral staircase, hardwood flooring, a white armchair, and decorative wall art.
    Dec 28 - Jan 3

    Casa Mallet by Wynwood House + Flight

    Casco Viejo
    6 nights
    3.5 star property
    9.8/10 - Exceptional (30 reviews)
    "I would highly recommend, the service I received was impeccable and just a wonderful experience! I was a bit hesitant regarding the location but once I got there, it turned out to be perfect. The concierge staff was such a pleasure to work with especially ‘Jerry’, who provided recommendations and information. This was such a blessing to us. I would stay here again in a heart beat. It’s a must stay!"
    Reviewed September 16, 2026
    Roundtrip • Toronto (YTO) - Panama City (PTY)
    YYZ - PTY • 1 stop PTY - YYZ • 1 stop
    Save 100% on your flight
    CA $11,903
    CA $8,259
    per traveller
    found 1 day ago
    Casa Mallet by Wynwood House
  • An outdoor dining area with wooden tables and chairs, a thatched roof, and a view of the sea.
    Dec 11 - Dec 17

    Hotel San Pedro de Taboga + Flight

    Taboga
    6 nights
    3.0 star property
    9.6/10 - Exceptional (5 reviews)
    "Peronal muy amable y dispuestos ayudar en todo momento."
    Reviewed September 21, 2026
    Roundtrip • Toronto (YTO) - Panama City (PTY)
    YYZ - PTY • 1 stop PTY - YYZ • Nonstop
    CA $1,860
    CA $1,298
    per traveller
    found 14 hours ago
    Hotel San Pedro de Taboga

Where to stay in Santa Clara

Find the best Santa Clara areas and neighborhoods for the activities you enjoy most.
A coastal cityscape with a prominent church tower, a river, and distant mountains.

Casco Viejo

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.
A modern, spiraling skyscraper with a unique design, surrounded by other buildings in an urban setting.
Photo by Fabiola Tile
Open Photo by Fabiola Tile

Bella Vista

Bella Vista is highly notable for its popular shops, and you might want to visit top sights like Via Espana and Iglesia del Carmen. See more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina Station.
A city skyline with modern high-rise buildings and a river in the foreground.

El Cangrejo

The abundant dining options and casinos are top of the list for many visitors to El Cangrejo. A stop by Via Espana or Crown Casino might round out your trip.
A bridge over a body of water with several boats.

San Francisco

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.
A building with three arched windows, a balcony with wrought iron railings, and a tiled roof.

San Felipe

If you're spending some time in San Felipe, Independence Square and Interoceanic Canal Museum are top sights worth seeing.

Santa Clara Hotel Deals

A buffet with various food items including fruits, juices, and cheeses.

Courtyard by Marriott Panama Metromall

Courtyard by Marriott Panama Metromall
4.0 star property
3.2 km from Santa Clara
9.2 out of 10, Wonderful, (1,001 reviews)
"Staff was very good"
The price is CA $141
CA $156 total
includes taxes & fees
Nov 27 - Nov 28
Courtyard by Marriott Panama Metromall
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
See all properties in Santa Clara

Frequently Asked Questions

How much does a Santa Clara vacation package cost?

Custom make your Santa Clara vacation package from as little as CA $1,259. Pick from any combination of hotels, flights and rental cars to craft the escape of your dreams. Be sure to add on some tours and experiences!

How do I get a cheap travel package to Santa Clara?

One of the easiest ways to save cash (and time) is to bundle your bookings with Expedia. Hotels, rental cars, flights and activities — we've got them all. Select the combination that best fits you and watch your savings grow. Of course, a travel package is never a one-size-fits-all. That's why we offer more than 550 air carriers and 1,000,000 hotels throughout the world, which lets you customize your Santa Clara getaway.

Where should I stay in Santa Clara?

Most travelers who visit Santa Clara include Miraflores Locks and Metropolitan Cathedral of Panama on their must-see lists. Why not select a hotel close to one of these main attractions?

How far in advance should I book my Santa Clara vacation?

Savvy travelers always book early. Air carriers generally advertise flights up to a year prior to departure, and this is a fantastic opportunity to score some of the cheapest prices. Just been told you should take some vacation time next week? No need to worry. Expedia are never short on fantastic deals to whisk you away on the getaway of your dreams, at an affordable price.

What does an Expedia Santa Clara travel package include?

It comes down to what you're looking for. If you're traveling solo, you might decide to combine hotels and flights. Bringing the whole family to Santa Clara? A travel package including flights, hotels and rental cars might suit you better. Expedia gives you the flexibility and freedom to tailor-make your travel package.

What should I know before booking a Santa Clara travel package?

When you book your flights, hotels and car rentals together, you'll pick up awesome discounts. Whether you're organizing a beach break in a villa or prefer to stay in an upscale city hotel, Expedia can make it happen for less.

Can I choose my airline with a Santa Clara Expedia vacation package?

Yes, you can. We offer more than 550 airline partners throughout the world, so opt for the carrier that fits your budget and travel needs.

If I'm not able to travel, can I cancel my Santa Clara vacation package?

Because we understand life is full of surprises, the answer is yes. For further details, check out our Customer Service Portal. But generally speaking, if you've made your booking in the last 24 hours, you may be able to change or cancel it for no charge. Your hotel, airline or car rental company may impose a fee if you made your booking a while ago.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.