Santa Clara Vacation Packages

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to CA $4,200 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Your Santa Clara Vacation

Lock in a Santa Clara vacation package that has everything you need without any unnecessary extras. Great for distilleries and craft breweries, bars and pubs and cafes, think about staying in the neighborhood of El Cangrejo. A trip to Santa Clara is an excellent opportunity to take in the sights. Make sure you visit big-name attractions such as Multiplaza Pacific Mall, Avenida Balboa and Via Espana. A few clicks is all it takes to create a customized Santa Clara vacation on Expedia.

Top Holiday Package Deals in Santa Clara

Price found within the past 48 hours. Click for updated prices.
Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

4 out of 5
Price was CA $1,760, price is now CA $1,236 per person
CA $1,236
per person
Aug 24 - Aug 29
found 1 day ago
Roundtrip flight included
Montreal (YMQ) to Panama City (PTY)
8.4/10 Very Good! (1,832 reviews)
The staff were very friendly. The food was ok at best. The breakfast was very limited and not very appetizing. The only thing near this hotel is the airport.

Reviewed on Jun 16, 2026

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Price was CA $2,556, price is now CA $1,445 per person
CA $1,445
per person
Aug 24 - Aug 29
found 1 day ago
Roundtrip flight included
Montreal (YMQ) to Panama City (PTY)
9.2/10 Wonderful! (1,008 reviews)
Spacious and modern room with large bathroom and nice shower. Beautiful music during the day and evening. Excellent breakfast buffet and on-site dining. Pool and pool bar were lovely. Friendly staff. Highly recommend.

Reviewed on Jun 14, 2026

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Price was CA $3,127, price is now CA $1,832 per person
CA $1,832
per person
Jul 25 - Aug 1
found 1 day ago
Roundtrip flight included
Montreal (YMQ) to Panama City (PTY)
8.4/10 Very Good! (1,553 reviews)
Rooms clean and spacious

Reviewed on Jun 16, 2026

Casa Mallet by Wynwood House

Casa Mallet by Wynwood House

4 out of 5
Casco Viejo
Price was CA $2,659, price is now CA $1,918 per person
CA $1,918
per person
Aug 23 - Aug 30
found 12 hours ago
Roundtrip flight included
Montreal (YUL) to Panama City (PTY)
9.8/10 Exceptional! (27 reviews)
In the middle of the old town, lovely rooftop. Beautiful apartment. Easy check in. WhatsApp line is available if anything was needed or if we had questions.

Reviewed on Mar 12, 2026

Villa Marina Hotel

Villa Marina Hotel

3.5 out of 5
Price was CA $1,855, price is now CA $1,338 per person
CA $1,338
per person
Aug 23 - Aug 30
found 12 hours ago
Roundtrip flight included
Montreal (YUL) to Panama City (PTY)
9/10 Wonderful! (161 reviews)
The room was spotless clean! The staff was always helpful and ready to serve. Breakfast and food in general was very tasty. The Bar is quite complete

Reviewed on Jun 13, 2026

Where to stay in Santa Clara

Find the best Santa Clara areas and neighborhoods for the activities you enjoy most. Learn more about Santa Clara
View of the Panama City Old Town

Casco Viejo

4/5(32 area reviews)

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

Find hotels in Casco Viejo

Santa Clara Hotel Deals

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
The price is CA $213 per night from Jul 2 to Jul 3
CA $213
CA $234 total
Jul 2 - Jul 3
includes taxes & fees
9/10 Wonderful! (5,603 reviews)
"Amazing breakfast. Uncomfortable bed. Very stiff. Super thick high pillows. Also only a single sheet on bed, no blanket. Bed situation very unfortunate. Breakfast salvaged it but that’s not why you sleep somewhere"

Reviewed on Jun 18, 2026

Hotel Riu Plaza Panama
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz Tocumen Panama
Fully refundable
The price is CA $192 per night from Jun 28 to Jun 29
CA $192
CA $220 total
Jun 28 - Jun 29
includes taxes & fees
8.6/10 Excellent! (2,616 reviews)
"When you walk in it smells very nice, very clean. The staff provide good services, very friendly, The rooms are very elegant, and clean, the utilities are great. They provide transportation from the airport. Delicious breakfast, fresh lemon water to drink. With a area for your business needs. The ..."

Reviewed on Jun 17, 2026

Crowne Plaza Panama Airport by IHG
Sheraton Grand Panama

Sheraton Grand Panama

4 out of 5
Via Israel And 77th Street Panama City Panama
Fully refundableReserve now, pay when you stay
The price is CA $192 per night from Jun 27 to Jun 28
CA $192
CA $211 total
Jun 27 - Jun 28
includes taxes & fees
8.6/10 Excellent! (1,000 reviews)
"Everything is great"

Reviewed on Jun 9, 2026

Sheraton Grand Panama
See all 1,767 properties in Santa Clara
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Family Vacations
Family Vacations

Frequently asked questions

How much does a Santa Clara vacation package cost?
Custom make your Santa Clara vacation package from as little as CA $1,236. Pick from any combination of hotels, flights and rental cars to craft the escape of your dreams. Be sure to add on some tours and experiences!
How do I get a cheap travel package to Santa Clara?
One of the easiest ways to save cash (and time) is to bundle your bookings with Expedia. Hotels, rental cars, flights and activities — we've got them all. Select the combination that best fits you and watch your savings grow. Of course, a travel package is never a one-size-fits-all. That's why we offer more than 550 air carriers and 1,000,000 hotels throughout the world, which lets you customize your Santa Clara getaway.
Where should I stay in Santa Clara?
Most travelers who visit Santa Clara include Miraflores Locks and Metropolitan Cathedral of Panama on their must-see lists. Why not select a hotel close to one of these main attractions?
How far in advance should I book my Santa Clara vacation?
Savvy travelers always book early. Air carriers generally advertise flights up to a year prior to departure, and this is a fantastic opportunity to score some of the cheapest prices. Just been told you should take some vacation time next week? No need to worry. Expedia are never short on fantastic deals to whisk you away on the getaway of your dreams, at an affordable price.
What does an Expedia Santa Clara travel package include?
It comes down to what you're looking for. If you're traveling solo, you might decide to combine hotels and flights. Bringing the whole family to Santa Clara? A travel package including flights, hotels and rental cars might suit you better. Expedia gives you the flexibility and freedom to tailor-make your travel package.
What should I know before booking a Santa Clara travel package?
When you book your flights, hotels and car rentals together, you'll pick up awesome discounts. Whether you're organizing a beach break in a villa or prefer to stay in an upscale city hotel, Expedia can make it happen for less.
Can I choose my airline with a Santa Clara Expedia vacation package?
Yes, you can. We offer more than 550 airline partners throughout the world, so opt for the carrier that fits your budget and travel needs.
If I'm not able to travel, can I cancel my Santa Clara vacation package?
Because we understand life is full of surprises, the answer is yes. For further details, check out our Customer Service Portal. But generally speaking, if you've made your booking in the last 24 hours, you may be able to change or cancel it for no charge. Your hotel, airline or car rental company may impose a fee if you made your booking a while ago.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.